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Oct 6, 2008 5:15 pm US/Pacific

$600K Given To City Of Hope Breast Cancer Research

City of Hope received a three-year grant totaling $600,000 from the Susan G. Komen for the Cure today to fund research on the side effects of hormone-dependent breast cancer.

Researchers will use the money to determine how to reduce the side
effects of aromatase inhibitors -- typically joint pain, bone loss and
fractures -- which are used to fight cancer in postmenopausal women. Patients undergoing long-term treatment can also develop a resistance to aromatase inhibitors.

A drug known as LBH589 may prevent side effects and drug resistance.

"The Susan G. Komen for the Cure grant will help us understand how
LBH589 works and explore whether a combination of typical aromatase inhibitors with this drug will produce a synergistic effect," said Shiuan Chen, director of Tumor Cell Biology, Beckman Research Institute at City of Hope.

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